Childbearing history associated with improved survival in choroidal melanoma.

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Abstract
INTRAOCULAR MELANOMA is the only potentially fatal eye tumor in adults. Established prognostic factors include tumor size, patient age, and histologic cell type, among others.1 The current investigation was motivated by studies in which cutaneous melanoma showed women to have a better prognosis than men.2-8 In a few studies8-10 the advantage was limited to women who had given birth. To investigate the possible role of childbearing in melanoma of the uveal tract, we prospectively evaluated a large cohort of individuals with these tumors after a detailed reproductive history had been collected from the women during baseline examination.