THE ATTENUATION OF EXERCISE-INDUCED BRONCHOSPASM BY ASCORBIC-ACID

  • 1 January 1982
    • journal article
    • research article
    • Vol. 49  (3) , 146-151
Abstract
The potential benefit of ascorbic acid in asthma was studied in exercise-induced bronchospasm (EIB). Asthmatic subjects (12) were recruited on the basis of findings compatible with EIB. On 2 subsequent days, the subjects ingested 500 mg of ascorbic acid or a placebo. The study was performed in a double-blind randomized fashion. Partial and maximal expiratory flow (PEFV and MEFV) curves were used to determine pulmonary function changes. Pretreatment with ascorbic acid led to a significant attenuation of the bronchospasm seen 5 min after exercise compared to placebo, as measured by FVC [forced vital capacity] (0.23 .+-. 0.08 l decrease after ascorbic acid, 0.48 .+-. 0.14 l decrease after placebo) and by FEV1 [forced expiratory vol in 1 s] (0.24 .+-. 0.06 l decrease after ascorbic acid, 0.44 .+-. 0.14 l decrease after placebo) (Mean .+-. SE). A mild antibronchospastic action of ascorbic acid in subjects with EIB is suggested.

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