HB Silver Springs [β131(H9)GLNHIS], A New Hemoglobin Variant Found in Six African-Americans

Abstract
We report a new hemoglobin variant which we have named Hb Silver Springs. This variant results from a substitution CAGĆC (GlnHis) at codon 131 of the β chain. It was detected only by cation exchange high performance liquid chromatography. This is the fifth reported substitution at codon 131. This variant does not appear to have any clinical or hematologic manifestations.