Evaluation of the in-vitro activity of furopenem (SY5555 or SUN5555) against respiratory tract pathogens and β-lactamase producing bacteria

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Abstract
Furopenem is a novel orally active penem. In this study, furopenem was highly active in vitro against Streptococcus pneumoniae (MIG90 0.03 mg/L), Haemophilus influenzae (MIC90, 2 mg/L), and Moraxella catarrhalls (MIG90, 0.5 mg/L). Its activity was not reduced by a variety of β-lactamase enzymes, however β-lactam resistance by other mechanisms was associated with higher MICs.

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