Antimicrobial therapy of gynaecological infections: an overview

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Abstract
Gynaecological infections are diverse in aetiology and clinical presentation. Clinical diagnosis is frequently imprecise, and selection of appropriate antimicrobial therapy is often empiric. Since such infections are usually polymicrobial and involve mixed aerobes and anaerobes of vaginal origin, agents with broad-spectrum activity against these micro-organisms are preferred. In serious infections, combination therapy with an aminoglycoside plus clindamycin, cefoxitin or cefotaxime is indicated. The prospect of single agent therapy with newer agents such as mezlocillin, piperacillin, formimidoyl thienamycin or moxalactam for such infections remains to be determined by controlled clinical trials.

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