Surface characteristics and protein adsorption on combinatorial binary Ti‐M (Cr, Al, Ni) and Al‐M (Ta, Zr) library films
- 20 February 2009
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part A
- Vol. 92A (2) , 521-532
- https://doi.org/10.1002/jbm.a.32398
Abstract
Systematic studies of protein adsorption onto metallic biomaterial surfaces are generally lacking. Here, combinatorial binary library films with compositional gradients of Ti1-xCrx, Ti1-xAlx, Ti1-xNix and Al1-xTax, (0 1-yZry (0 < y 2 and Al2O3 preferentially forming on the binary film surfaces. Correspondingly, protein adsorption onto these films closely correlated with their surface oxide fractions. Aluminum deposited as either a constant-composition film or as part of a binary library consistently adsorbed the least amount of albumin and fibrinogen, with alumina-enrichment of the surface oxide correlating with this adsorption. Overall, this combinatorial materials approach coupled with high-throughput surface analytical methods provides an efficient method of screening potential metallic biomaterials that may enable as well systematic studies of surface properties driving protein adsorption on these metal / metal oxide systems. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010Keywords
This publication has 53 references indexed in Scilit:
- Bring That Pioneering Spirit Back! A 25-Year Perspective on the Vascular StentCardioVascular and Interventional Radiology, 2007
- Quantification of the kinetics and thermodynamics of protein adsorption using atomic force microscopyJournal of Biomedical Materials Research Part A, 2005
- Integration of Combinatorial Synthesis, Rapid Screening, and Computational Modeling in Biomaterials DevelopmentMacromolecular Rapid Communications, 2004
- Economical Sputtering System To Produce Large-Size Composition-Spread Libraries Having Linear and Orthogonal Stoichiometry VariationsChemistry of Materials, 2002
- Electrochemical Studies of the Adsorption Behavior of Serum Proteins on TitaniumLangmuir, 2000
- Ellipsometric Study of Bovine Serum Albumin Adsorbed onto Ti/TiO2 ElectrodesJournal of Colloid and Interface Science, 1999
- Electrochemical Studies of the Adsorption Behavior of Bovine Serum Albumin on Stainless SteelLangmuir, 1999
- Protein interaction with tantalum: Changes with oxide layer and hydroxyapatite at the interfaceJournal of Biomedical Materials Research, 1992
- Fibrinogen–aluminium interaction: Changes with oxide layer thickness onto metal surfaceJournal of Biomedical Materials Research, 1990
- Enhanced Protein Adsorption at the Solid-Solution Interface: Dependence on Surface ChargeScience, 1973