CHEMICAL CHANGES OCCURRING IN THE BODY AS THE RESULT OF CERTAIN DISEASES

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Abstract
Compo ition of the blood serum in severe diabetic acidosis and during recovery was studied as follows: The concentrations of the principal normal anions, Cl'', HCO3'', protein'', HPO4", and lac-tate'', and the actual pH were determined. Total base was determined directly, and from its value and the sum of the 5 principal acids determined, the concentration or undetermined acid (presumably chiefly ketone acid) was obtained. The principal non-electrolyte substances, non-protein N (urea), and dextrose were determined. Freezing point of the serum was determined, and compared with theoretical total osmolar concentration (calculated from the individual acids, total base, glucose, and urea).

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