Contribution of MHC class I chain-related A (MICA) gene polymorphism to genetic susceptibility for systemic lupus erythematosus
Open Access
- 2 November 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 44 (3) , 287-292
- https://doi.org/10.1093/rheumatology/keh459
Abstract
Objective. To evaluate the contribution of the MHC class I chain-related A (MICA) gene polymorphism to the genetic risk of systemic lupus erythematosus (SLE). Methods. HLA-DRB1-DQA1-DQB1 genotyping, MICA exon 5 microsatellite genotyping and HLA-B8 genotyping were performed in 48 Italian SLE patients and in 158 healthy control subjects. Results. Of HLA class II haplotypes, only DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2) was significantly more frequent among SLE patients than among healthy control subjects [odds ratio (OR) = 6.5, corrected PP = 0.005). The allele-wise comparison between patients and controls showed that both MICA5 (OR = 2.5, corrected PPPP22.6, corrected PPP30.3) in DR3-DQ2-positive subjects carrying the MICA5-5.1 genotype. Conclusions. Our study provides the first demonstration of the independent association of the MICA gene polymorphism with genetic risk of SLE.Keywords
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