Very close linkage between D2S1 and ACP1 on chromosome 2p

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Abstract
Summary: The genomic DNA‐probe L2.30 was used to assign D2S1 to 2p23–pter by in situ hybridization. The RFLP revealed by BglII was then used for linkage studies in the Oslo‐NHIK families segregating for the acid phosphatase ACPl protein polymorphism. Evidence for very close linkage was found by a lod score of +17.17 at recombination fraction θ= 001. By this close linkage 92 informative meioses could be inferred from the families and with only a single crossover. The upper probability limit to the recombination fraction is 006 according to the HGM 8 criterion. No association between ACP1 alleles and D2S1 BglII alleles was found. The Norwegian gene frequencies for 0251 were A1 (9–0 kb) = 065 and A2 (6.3 kb) = 0.35.