Effects of MPTP on the cerebrovasculature
- 1 January 1991
- journal article
- Published by Wiley in International Journal of Developmental Neuroscience
- Vol. 9 (2) , 155-159
- https://doi.org/10.1016/0736-5748(91)90006-8
Abstract
The neurotoxin, l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine, has been shown to cause pooling of blood in the brain microvasculature and decrease the permeability of the blood-brain barrier. All areas of the brain examined in this study were affected. This study points out the possibility that reduced nutrient uptake, hypoxia and ensuing free radical damage are involved in the mechanism of toxicity of this neurotoxin.Keywords
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