MOLECULAR STRUCTURAL STUDIES OF LICHEN SUBSTANCES WITH ANTIMICROBIAL, ANTIPROLIFERATIVE, AND CYTOTOXIC EFFECTS FROMParmelia subrudecta
- 23 September 2010
- journal article
- research article
- Published by Taylor & Francis in Preparative Biochemistry & Biotechnology
- Vol. 40 (4) , 377-388
- https://doi.org/10.1080/10826068.2010.525432
Abstract
Lecanoric acid (1), orsellinic acid methyl ester (2), orcinol (3), and usnic acid (4) were isolated from the lichen Parmelia subrudecta, collected on Palma of the Canary Islands, Spain. Compounds 1, 2, 3, and 4 were purified by solvent extraction, silica gel column chromatography, and preparative high-performance liquid chromatography (HPLC) consecutively. The structures of the four compounds were elucidated by one- and two-dimensional nuclear magnetic resonance (NMR) experiments and mass spectrometric investigations. These compounds showed activity against important gram-positive and gram-negative pathogens like mycobacteria and multiresistant staphylococci. This activity is combined with antiproliferative activity and cytotoxicity.Keywords
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