ADRIAMYCIN AND ADRIAMYCIN-DNA NEPHROTOXICITY IN RATS

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 50  (2) , 190-196
Abstract
The early nephrotoxicity of free and DNA-bound adriamycin (ADR) [an antineoplastic drug] was compared in left nephrectomized rats. Free ADR induced progressive renal failure within 3 wk, in association with renal changes characterized by severe tubular distention and vacuolization of podocytes in glomeruli. Renal function remained normal and renal lesions were discrete in animals treated with ADR bound to DNA. Thus, the binding of ADR to DNA seems to reduce the early nephrotoxicity of free ADR.