The Influence of Orally-Administered Vitamin C or Zinc on the Absorption of and the Biological Response to Lead

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Abstract
A single blind study was performed on male workers from a primary Pb smelter to determine whether a daily oral supplement of vitamin C (1 g vitamin C orally once/day, 5 times/wk for 20 wk) or Zn (60 mg Zn as zinc gluconate once/day, 5 times/wk for 8 wk) influenced the absorption of and the biological (hematological and renal) response to Pb. The vitamin C and the Zn study groups comprised 39 and 11 workers, respectively. Their blood levels of Pb at the start of the experiment ranged from 28.9-76.4 .mu.g/100 ml. A matched control group receiving a placebo was followed simultaneously. In workers whose exposure to nonorganic Pb was moderate and who did not suffer from nutritional deficiencies, oral supplementation of vitamin C or Zn did not influence the metabolism and biological action of Pb.

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