The hairless mouse as a model for evaluating sunscreens. Prevention of ultraviolet B inhibition of epidermal DNA synthesis
- 1 April 1980
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 116 (4) , 419-421
- https://doi.org/10.1001/archderm.116.4.419
Abstract
A sunscreen''s effectiveness is usually determined by its ability to prevent UV radiation-induced skin erythema. This criterion requires subjective interpretation. A new method of evaluating sunscreens is proposed based on the known effect of UV-B radiation (290-320 nm) to inhibit DNA synthesis. Hairless mice were used; sulisobenzone (Uval) and aminobenzoic acid (Pre-Sun) sunscreens differ substantially in their ability to prevent inhibition of epidermal cell DNA synthesis by UV-B radiation. By estimating the UV-B dose required to inhibit DNA synthesis by 50%, with and without sunscreen, a protective factor of 5.6 and 14.4 was calculated for sulisobenzone and aminobenzoic acid, respectively. This is an objective way to evaluate sunscreen effectiveness and could be a useful screening procedure for sunscreen preparations before final efficacy testing in humans.This publication has 1 reference indexed in Scilit:
- Performance of six sunscreen formulations on human skin: a comparisonArchives of Dermatology, 1979