THE EFFECT OF THYROIDECTOMY ON THE TISSUE RESPONSE TO ADMINISTERED THYROXIN

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Abstract
The rats med were both ? and ?, about 6 mos. old, weighing between 200 and 250 gm. The O2 uptake was detd. on slices in the Warburg apparatus. In the thyroidectomized animals, the operation was performed 4-6 wks. prior to the expt. d-1-Thyroxin, 20 mg./kg., was injd. subcut. 48 hrs. before the expt. in a single dose. The Q02 of normal livers was 10.5 + 0.59; that of livers from thyroxin injd. rats was 12.7 + 0.64, an increase of 21%. While this is statistically significant, the margin is not large. The QO2 of the liver of thyroidectomized animals was 8.3 + 0.41, or 21% less than the normal animal; after thyroxin, it rose to 12.3 [plus or minus] 0.49, representing an increase of 48%. In the case of the kidney, while previous thyroidectomy decreases the O2 consumption, it does not apparently sensitize the tissue to the effects of thyroxin.

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