Urinary Enzymes and Calcium Oxalate Urolithiasis

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Abstract
Male Sprague-Dawley rats were challenged with various hyperoxaluric agents including ammonium oxalate, hydroxy-L-proline, and ethylene glycol. All treatments resulted in increased urinary oxalate. Associated with hyperoxaluria was increased in urinary levels of renal enzymes, gamma-glutamyl transpeptidase, N-acetyl-.beta.-glucosaminidase, and alkaline phosphatase. Most of the rats did not demonstrate any significant change in urinary levels of .beta.-galactosidase. There was a higly significant positive correlation between urinary oxalate and N-acetyl-.beta.-glucosaminidase.