RNA Metabolism in Lymphocytes Stimulated by Phytohemagglutinin: Initial Responses to Phytohemagglutinin
Open Access
- 1 June 1965
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 25 (6) , 1014-1027
- https://doi.org/10.1182/blood.v25.6.1014.1014
Abstract
The initial changes in lymphocyte RNA metabolism produced by treatment with phytohemogglutinin (PHA) are described. The earliest change was a decrease in total RNA (i-RNA), detectable after 30 minutes of exposure to PHA. This loss could not be localized to any of the major types of cellular RNA. After 1 hour, accelerated synthesis of RNA, shown by incorporation of u-H3, was detected, and a progressive increase in rate of synthesis continued for 24 hours. The significance of the early loss of RNA as related to the onset of lymphocyte growth is discussed.Keywords
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