Inhibition of Src Tyrosine Kinase as Treatment for Human Pancreatic Cancer Growing Orthotopically in Nude Mice
Open Access
- 1 December 2004
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 10 (23) , 8028-8036
- https://doi.org/10.1158/1078-0432.ccr-04-0621
Abstract
Purpose: The Src family comprises a family of nonreceptor intracellular tyrosine kinases that mediate a variety of cellular pathways. Src kinases are overexpressed in a variety of human tumors, including cancer of the colon, breast, and pancreas, and they are an integral part of tumor cell signaling pathways associated with migration, proliferation, adhesion, and angiogenesis.Keywords
This publication has 25 references indexed in Scilit:
- Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-SrcJournal of Medicinal Chemistry, 2004
- Chemotherapy for pancreatic cancerAlimentary Pharmacology & Therapeutics, 2003
- Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT CascadesJournal of Biological Chemistry, 2003
- VEGF differentially activates STAT3 in microvascular endothelial cellsThe FASEB Journal, 2003
- Src activation regulates anoikis in human colon tumor cell linesOncogene, 2002
- Effect of the vascular endothelial growth factor receptor‐2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude miceInternational Journal of Cancer, 2002
- Update on pancreatic cancerCurrent Opinion in Oncology, 2002
- Inhibition of Growth and Metastasis of Human Pancreatic Cancer Growing in Nude Mice by PTK 787/ZK222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine KinasesCancer Biotherapy & Radiopharmaceuticals, 2001
- Src Family Tyrosine Kinases and Growth Factor SignalingExperimental Cell Research, 2000
- The Src SH3 Domain Is Required for DNA Synthesis Induced by Platelet-derived Growth Factor and Epidermal Growth FactorJournal of Biological Chemistry, 1996