EFFECT OF ADRENAL CORTEX EXTRACT ON CAPILLARY PERMEABILITY

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Abstract
An inflammatory exudate induced an increase in capillary permeability. This was manifested by the accumulation of trypan blue from the circulation in a cutaneous area previously injected with an exudate. This effect was likewise duplicated by leukotaxine, a nitrogenous substance extracted from inflammatory exudates. The effect of an exudate or of leukotaxine of increasing capillary permeability was wholly or in part inhibited by the presence of an extract of the adrenal cortex. This inhibitory effect could be brought about by adding the hormonal prep, to the exudative material and then injecting the mixture into the cutaneous tissue of a normal rabbit. Similar results were attained by separate injs., several mins. to hrs. apart and at the same site, of the hormone followed by either the exudative material or leukotaxine. The apparent property of the hormone of the adrenal cortex to influence capillary filtration and therefore its possible significance in various conditions such as traumatic or secondary shock was pointed out. The practical and relatively simple technical procedure utilized in the present series of expts. suggested the possibility of a convenient method for assaying various extracts of the adrenal cortex.