Formation of a reticuloendothelial-depressing substance in the ischemic intestine

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Abstract
The phagocytic index of the reticuloendothelial system of normotensive assay dogs was determined by measuring the clearance of carbon particles from the blood. These animals were cross-transfused with portal venous blood from experimental dogs bled to a mean arterial pressure of 40 mm Hg for 90 min. The superior mesenteric artery of the experimental animal was perfused at a normal rate of 8.8 ml/kg/min in half of the experiments and at a rate of 3.2 ml/kg/min (equivalent to rates prevailing in hemorrhagic hypotension) in the remaining experiments. Statistical comparison showed a significantly greater (P < 0.01) depression of reticuloendothelial activity in the group with lower flows. The results strongly suggest that a humoral reticuloendothelial-depressing substance is formed in the ischemic intestine of dogs subjected to hemorrhagic hypotension.