Paromomycin in Cryptosporidiosis

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Abstract
Sir—Hewitt and colleagues should be commended for publishing the findings of their placebo-controlled trial of paromomycin for the treatment of cryptosporidiosis [1]. Their results are similar to those noted in a previous placebo-controlled trial and in other open-label treatment studies [2, 3]. However, several weaknesses in the trial design and analysis may have led the authors to incorrect conclusions.