On the preparation of L-[2,3-3H2]phenylalanine and L-[2,3-3H2]tyrosine
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 645-647
- https://doi.org/10.1039/p19750000645
Abstract
Specimens of L-[2,3-3H2]phenylalanine and L-[2,3-3H2]tyrosine, prepared via reduction of acylaminocinnamic derivatives with tritium gas, have been degraded to establish the tritium labelling patterns. Both amino-acids were found to be labelled approximately equally at C-2 and -3 with the tritium at C-3 in predominantly the pro-S position. Catalytic hydrogenation of (Z)-(α-acetamido[β-2H]cinnamyl)-L-glutamic acid was used to demonstrate, by n.m.r. spectroscopy, the stereochemical course of the tritiation.Keywords
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