T lymphocyte anergy during acute infectious mononucleosis is restricted to the clonotypic receptor activation pathway
Open Access
- 1 July 1992
- journal article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 89 (1) , 83-88
- https://doi.org/10.1111/j.1365-2249.1992.tb06882.x
Abstract
The transient T cell anergy associated with acute infectious mononucleosis (IM) caused by the Epstein Barr virus has been analysed in a sample of 14 IM children. Peripheral blood mononuclear cells (PBMC) obtained from IM patients showed a significant specific impairment in their proliferative response to both phytohaemagglutinin (PHA; P P in vivo situations). This and other similar experimental approaches to transient secondary immunodeficiencies may help to unravel the physiopathological role of different surface molecules in T cell activation.Keywords
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