GENETIC RELATIONSHIPS OF Mlsa AMONG POLYMORPHIC LOCI ON DISTAL MOUSE CHROMOSOME 1
- 1 February 1988
- journal article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 15 (1-3) , 59-66
- https://doi.org/10.1111/j.1744-313x.1988.tb00408.x
Abstract
The segregation of Mlsa with respect to genes localized distally on mouse chromosome 1 was examined in two sets of recombinant inbred (RI) strains. In order to localize Mlsa, a linkage map based on analysis of both interspecific backcross mice and multiple sets of RI strains was utilized: (centromere) - Ren-1,2-10 centimorgans (cM)-At-3-8cM.-Apo-A2/Ly-17-2 cM-Spna-1-4cM.-Akp-1-(telomere). The Mlsa allele was mapped to a region that extended just centromeric of Ly-17 (one crossover in 40 RI strains) to just telomeric of Spna-1 (no crossover in 40 RI strains). The identification of multiple polymorphic loci in the region of Mlsa should allow precise gene localization and assist in efforts to clone this gene.Keywords
This publication has 24 references indexed in Scilit:
- Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group.The Journal of Experimental Medicine, 1988
- Establishment of a molecular genetic map of distal mouse chromosome 1: Further definition of a conserved linkage group syntenic with human chromosome 1qGenomics, 1988
- Clonal analysis of the Mls system. A reappraisal of polymorphism and allelism among Mlsa, Mlsc, and Mlsd.The Journal of Experimental Medicine, 1987
- Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer LocusScience, 1987
- Mapping of alpha-spectrin on distal mouse chromosome 1Cytogenetic and Genome Research, 1987
- Structural Heterogeneity and Functional Domains of Murine Immunoglobulin G Fc ReceptorsScience, 1986
- Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal locationNature, 1986
- Detection of deletions spanning the Duchenne muscular dystrophy locus using a tightly linked DNA segmentNature, 1985
- Assignment of the human antithrombin III structural gene to chromosome 1q23–25Cytogenetic and Genome Research, 1985
- Tissue and gene specificity of mouse renin expression.Hypertension, 1984