Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment
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Open Access
- 1 May 2003
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 60 (5) , 729-736
- https://doi.org/10.1001/archneur.60.5.729
Abstract
ALZHEIMER DISEASE (AD) is characterized by severe and progressive memory loss that interferes with daily living activities. Mild impairments of memory are typical of "normal" aging.1-3 Some individuals display an isolated loss of memory that is more severe than what would be expected on the basis of age alone but without the additional impairments of other cognitive domains or disruption of daily living activities characteristic of AD. This condition has been labeled mild cognitive impairment (MCI).4-6 Although focal memory loss may have heterogeneous origins,7 individuals with MCI convert to AD at a higher rate than do individuals without cognitive impairment,5,8 suggesting that, in many cases, MCI may represent an intermediate stage between aging and AD.Keywords
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