Comparative cytotoxicity of four nickel compounds to canine and rodent alveolar macrophages in vitro
- 1 September 1986
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 19 (1) , 105-110
- https://doi.org/10.1080/15287398609530911
Abstract
Nickel subsulfide (Ni 3 S 2 ), nickel sulfate (NiSO 4 ), nickel chloride (NiCl 2 ), and nickel oxide (NiO), are four compounds encountered by workers in the nickel‐refining and electroplating industries. These compounds were tested for their relative toxicity to beagle dog and F344/Crl rat alveolar macrophages in vitro. Dog alveolar macrophages were at least 10 times more sensitive to the effects of each of the 4 nickel compounds than were rat alveolar macrophages. Toxicity ranking of the four nickel compounds to macrophages from both species was Ni 3 S 2 > NiCl 2 ∼ NiSO 4 > NiO.Keywords
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