Eosinophilia associated with proliferation of CD3 ⁺ 4 ⁻ 8 ⁻ αβ ⁺ T cells with chromosome 16 anomalies

1 January 1996

journal article
Published by Wiley in British Journal of Haematology

Vol. 92 (2) , 315-317
https://doi.org/10.1046/j.1365-2141.1996.d01-1482.x

Abstract

We describe a patient with eosinophilia and an abnormal CD3⁺4⁻8⁻αβ⁺ T‐cell population. Chromosomal analysis of sorted CD3⁺4⁻8⁻ cells revealed abnormal karyotypes on chromosome 16. In the presence of IL‐2 the production of IL‐5 from CD3⁺4⁻8⁻ cells was higher than that from CD3⁺4⁺/8⁺ cells. Eosinophil survival‐enhancing activity in the patient serum was inhibited by a combination of anti‐IL‐5 and anti‐GM‐CSF monoclonal antibodies. These data suggest that increased production of IL‐5 and GM‐CSF from the abnormal CD3⁺4⁻8⁻ cells might cause eosinophilia.

Keywords

IL 5

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Eosinophilia associated with proliferation of CD3 + 4 − 8 − αβ + T cells with chromosome 16 anomalies

Abstract

Keywords

Eosinophilia associated with proliferation of CD3 ⁺ 4 ⁻ 8 ⁻ αβ ⁺ T cells with chromosome 16 anomalies