Aconitase, a two‐faced protein: enzyme and iron regulatory factor 1 2
- 1 December 1993
- journal article
- review article
- Published by Wiley in The FASEB Journal
- Vol. 7 (15) , 1442-1449
- https://doi.org/10.1096/fasebj.7.15.8262329
Abstract
In this brief survey, the path of development of our knowledge of the iron-sulfur enzyme aconitase [citrate(isocitrate)hydrolyase EC4.2.1.3.] is traced from its discovery in 1937. Particular emphasis is on developments in the past decade, when EPR, Mössbauer and electron nuclear double resonance spectroscopies, X-ray crystallography, and mutational analysis were applied to the problem. More recently discovered was the significant amino acid sequence identity between mitochondrial aconitase and the iron regulatory factor or iron-responsive element binding protein (IRE-BP). This has led to the realization that IRE-BP is an alternative form of cytosolic (not of mitochondrial) aconitase that is devoid of its cubane Fe-S cluster.Keywords
This publication has 0 references indexed in Scilit: