Metabolic fluctuation during a muscle contraction cycle
- 1 March 1998
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Cell Physiology
- Vol. 274 (3) , C846-C852
- https://doi.org/10.1152/ajpcell.1998.274.3.c846
Abstract
Gated31P-nuclear magnetic resonance followed the metabolic fluctuation in rat gastrocnemius muscle during a contraction cycle. Within 16 ms after stimulation, the phosphocreatine (PCr) level drops 11.3% from its reference state. The PCr minimum corresponds closely to the time of maximum force contraction. Pi increases stoichiometrically, while ATP remains constant. During a twitch, PCr hydrolysis produces 3.1 μmol ATP/g tissue, which is substantially higher than the reported 0.3 μmol ATP ⋅ twitch−1 ⋅ g tissue−1 derived from steady-state experiments. The results reveal that a substantial energy fluctuation accompanies a muscle twitch.Keywords
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