On the Relationship of Blood Group A to Rh Immunization and the Occurrence of Hemolytic Disease of the Newborn

Publisher Website
Google Scholar
Abstract
It was desired to determine whether a relationship could be established between the presence of group A in the red blood corpuscles and an increased incidence of response to immunization on the part of an Rh-negative woman bearing an Rh-positive fetus; and whether the presence or absence of hemolytic disease of the newborn could in part be related to the ABO blood group of the Rh-positive infant. In a sample of 228 sensitized Rh-negative women, 124 bore children afflicted with hemolytic disease of the newborn. Of these 124 women 66(or 53%) belonged to blood group A. The chi-square test indicates probable statistical significance and the inference is made that this unusual increase in incidence of blood group A mothers is not due to chance alone. These data indicate a possible relationship between blood group A of the mother and the character of her immune response to the Rh factor as antigen. The infants afflicted with hemolytic disease of the newborn showed a normal distribution of ABO blood groups.

This publication has 1 reference indexed in Scilit: