Treatment of colorectal cancer hepatic metastases by hepatic artery chemotherapy

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Abstract
Clinical experience with 69 patients with metastatic colorectal cancer to the liver treated with hepatic artery chemotherapy is reviewed. All patients have had a minimum of 6 mo. follow-up. The Infusaid implantable drug delivery system was used by direct laparotomy in 1/3, and via the transaxillary approach in the remaining 2/3. Two thirds of the patients had at least 25% of the liver replaced with tumor. Chemotherapeutic agents included FUdR [fluoro-2''-deoxyuridine] mitomycin C, and BCNU [1,3-bis-2-chloroethyl-1-nitrosourea]. The overall response rate was 51% and 69% for the 3-drug combination. Efficacy was not different in patients who had received prior systemic fluorouracil. Median survival from start of hepatic artery chemotherapy was 1 yr.