SENSITIVITY TO THIOURACIL
- 19 February 1944
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 124 (8) , 504-505
- https://doi.org/10.1001/jama.1944.62850080003009c
Abstract
In view of the recent reports1on the treatment of hyperthyroidism with thiouracil, several cases were selected for this type of therapy. Nine cases have been treated to date and three have exhibited manifestations of drug sensitivity. Our purpose in this report is to point out the toxic effects observed in the treatment of relatively few patients. It is not our desire at this time to comment on the efficacy of the drug in the treatment of hyperthyroidism. Case 1.— A man aged 55 complained of nervousness, sweating, weight loss, protrusion of the eyeballs, palpitation and exertional dyspnea. There was no past history of allergy. On examination there were noted moderate exophthalmos, an enlarged thyroid gland, moist palms and a tremor of the outstretched hands. The heart was overactive, with a rate of 120. The blood pressure was 150/70 mm. of mercury. The basal metabolic rate on two occasionsKeywords
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