Malignancy grading in oral squamous cell carcinoma. I. Squamous cell carcinoma of the tongue and floor of mouth: histologic grading in the clinical evaluation

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Abstract
In a retrospective histological and clinical study, a multifactorial grading system was used for histological classification and grading of malignancy in 51 cases of squamous cell carcinoma of the tongue and floor of mouth The results indicated that the use of such a multifactorial grading system, consisting of 7 morphological paramaeters, including an evaluation of both the tumor cell population itself and the tumor host relationship, can serve as an important supplement to clinical judgement in determining the outcome of the oral tumor.