Alkaloids and Biological Activity of Strychnos angolensis

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Abstract
A weak convulsant effect is found in the nonpolar part of the tertiary alkaloid extract of Strychnos angolensis Gilg, while the polar part shows a strong muscle–relaxant activity. Five indole alkaloids have been isolated from the nonpolar part of the extract. One is the known (+)–tubotaiwine while the others are derivatives of Wieland Gumlich aldehyde (WGA): 11–methoxy–WGA, 17–O–methyl–11–methoxy–WGA, 11–methoxy–diaboline and epi–17–O–methyl–11–methoxy–diaboline. Caracurine V, a tertiary dimeric alkaloid, is also found to be present in a toluene extract of bark of S. angolensis.

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