Metabolism of Coumarin and 4-Methylcoumarin by Rat-Liver Microsomes
- 1 February 1971
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 49 (2) , 177-184
- https://doi.org/10.1139/o71-026
Abstract
The metabolism of coumarin and 4-methylcoumarin by rat-liver microsomes has been studied. The major metabolites of coumarin in vitro, viz. 3- and 7-hydroxycoumarin, o-hydroxyphenyllactic acid, and o-hydroxyphenylacetic acid, were identified by thin-layer chromatography, and ultraviolet and fluorescence spectroscopy. Metabolites derived from 4-methylcoumarin in vitro have shown similar chromatographic and spectral characteristics as those of coumarin, suggesting that they are the methyl analogues of corresponding coumarin metabolites.Keywords
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