POST-TRANSPLANT MONITORING OF RENAL-ALLOGRAFT RECIPIENTS FOR T,B AND NULL LYMPHOCYTE SUBPOPULATIONS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 28  (1) , 123-129
Abstract
Time-course studies in 10 allograft recipients showed a significant reduction in the percentage of T [thymus-derived] cells in the immediate post-transplantation period. This was accompanied by an increase in the percentage of B [bone marrow-derived] and null cells. T, B and null cell percentages reverted to normal by the 6th mo. after transplantation, at a time when patients had achieved stable renal function and were receiving only maintenance immunosuppressive therapy. Similar trends were observed with regard to absolute number of T, B and null cells. Both pre- and post-transplant plasma samples failed to inhibit T-rosette formation. Transient B rosette inhibitory activity was observed in the plasma samples of 2 patients but did not appear to correlate with the mixed leukocyte culture blocking factor activity (MLC-BFA) of these plasma samples. In the group of patients studied there was no apparent association between percent or absolute T, B and null cell determinations and the onset of rejection crises.