A New Platelet‐Specific Antigen, Naka, Involved in the Refractoriness of HLA‐Matched Platelet Transfusion
- 1 October 1989
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 57 (3) , 213-217
- https://doi.org/10.1111/j.1423-0410.1989.tb00826.x
Abstract
Serum from a thrombocytopenic patient who was refractory to the transfusions of HLA-matched platelets contained a platelet-specific alloantibody, anti-Naka. Immunofluorescence analyses revealed that the Naka antigen defined by the serum was expressed exclusively on platelets and its distribution was different from PlA1, Baka, Yuka or Yukb. Analysis by Dr. von dem Borne's group revealed the Naka was also different from Koa, Kob or Zwb. Family studies showed that the Naka antigen was inherited as an autosomal codominant trait. Its antigen frequency in the Japanese population was over 97%. The results of the enzyme immunoassay using monoclonal antibodies for antigen immobilization showed that the Naka epitope did not appear to reside on GPIIb/IIIa or Ib. The transfusions of Naka-compatible platelets improved the patient's thrombocytopenia.This publication has 23 references indexed in Scilit:
- A New Platelet-Specific Alloantigen BraVox Sanguinis, 1988
- On the association of the platelet-specific alloantigen, Pena, with glycoprotein IIIa. Evidence for heterogeneity of glycoprotein IIIa.Journal of Clinical Investigation, 1987
- The Immunogenicity of Platelet Membrane GlycoproteinsTransfusion Medicine Reviews, 1987
- A new platelet-specific alloantigen system, Yuka/Yukb is located on platelet membrane glycoprotein IIIa.Proceedings of the Japan Academy, Series B, 1987
- Yuka, a New Platelet Antigen Involved in Two Cases of Neonatal Alloimmune ThrombocytopeniaVox Sanguinis, 1986
- Serological studies in patients on platelet‐ and granulocyte‐substitution therapyBritish Journal of Haematology, 1982
- Baka, a New Platelet‐Specific Antigen Involved in Neonatal Allo‐Immune ThrombocytopeniaVox Sanguinis, 1980
- Isolation and immunologic characterization of the human platelet alloantigen, P1A1Molecular Immunology, 1979
- Successful transfusion of platelets “mismatched” for HLA antigens to alloimmunized thrombocytopenic patientsAmerican Journal of Hematology, 1977
- Serological and Genetical Studies on a Platelet Antigen (Zw)Vox Sanguinis, 1959