The similarities and differences between meprobamate and barbiturates

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Abstract
The literature comparing meprobamate and the barbiturates is extensively reviewed, and the differences between these agents are found to be significant, from both pharmacological and clinical standpoints. These include major differences in site and mode of action, effects on conditioned responses and other animal behavior, primary indications for use in human beings, and effects on normal human behavior. The barbiturates are shown to be useful primarily as hypnotics which, in clinical doses, produce motor and intellectual impairment. Meprobamate is shown to be a specific antianxiety agent which produces no significant behavioral impairment at clinical dosage. A critique of this review follows.