Studies Pertaining to the Antibacterial Activity of Sulfathiazole and its Methyl Derivative

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Abstract
The antibacterial activity of the thiazole drugs was significantly greater in the synthetic medium employed than in ordinary nutrient broth. Viable cell counts made from cultures in synthetic medium containing sulfathiazole revealed an initial lag phase in drug-induced bacteriostasis. Similar counts made from nutrient broth cultures likewise exhibited an initial phase in drug action followed however by a period of increase, logarithmic in character but reduced in tempo. P-amino-benzoic acid and a few closely related compounds as well as a variety of bacteriological peptones and other commonly used ingredients of ordinary culture media were found to possess anti-sulfathiazole activity when tested under standardized conditions.