OSTEITIS FIBROSA INDUCED BY CALCIPHYLAXIS IN THE ABSENCE OF THE PARATHYROIDS

Abstract
Following a brief description of calciphylaxis, its influence upon the skeleton of the rat is described. After sensitization with dlhydro-tachysterol (DHT) challenge by subcutaneously administered ferric dextran (Fe-Dex) or egg white produces extensive topical calcium deposits and severe osteitis fibrosa. At a later stage this is followed by an excessive osteogenesis. All these reactions can proceed in the absence of the parathyroids.

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