THE CYCLICAL PATTERN OF RENAL EXCRETION DURING THE ADAPTATION OF NORMAL SUBJECTS TO ESOXYCORTICOSTERONEINDUCED SODIUM RETENTION*

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Abstract
The adaptation to prolonged mineralocorticoid administration was studied in 2 normal subjects receiving a constant weighed diet and daily intramuscular injections of 20 mg. of desoxycorticosterone acetate. After an initial phase of sodium retention and potassium loss (precyclical period), there was a cyclical phase characterized by depressions and elevations of urinary creatinine, osmolality, potassium, hydrogen ion, ammonia and phosphate, accompanied during the depressions by increases in free water loss, serum sodium concentration and osmolality (cyclical period). Sodium excretion increased progressively with each subsequent cyclical elevation of urinary creatinine and potassium, until levels of sodium intake were exceeded. It is postulated that this cyclical response to desoxycorticosterone-induced sodium retention is a heightening and compression of the normal 4-6 day cycle of sodium and water excretion, and that the ability to maintain or exaggerate such cycles may be a reflection of fluctuations in intrarenal hemodynamics.

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