The Effect of Beta-Receptor-Stimulating Agents on the Utero-Placental Blood Flow

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Abstract
The influence of salbutamol, a beta-2-receptor stimulating agent, on the blood flow through the utero-placental unit was evaluated in humans. Serial placenta scintigrams were analyzed quantitatively after injection of 0.5 mCi 13mIn by means of a .gamma.-camera connected on the line to a computer. The examinations were performed in the 3rd trimester of pregnancy. No sedation was used. Uterine contractions were not present. Salbutamol caused an increase in activity over the placental region corresponding to a 15% increase in blood volume. The rise time of the initial phase of isotope accumulation (calculated from 5-95% of final activity) was prolonged by 100% during salbutamol infusion. As the rise time is proportional to the volume/flow ratio of blood in the uteroplacental region, salbutamol infusion apparently causes a decrease in blood flow in the absence of uterine contractions.

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