Tight junctions and the modulation of barrier function in disease
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Open Access
- 16 April 2008
- journal article
- review article
- Published by Springer Nature in Histochemistry and Cell Biology
- Vol. 130 (1) , 55-70
- https://doi.org/10.1007/s00418-008-0424-9
Abstract
Tight junctions create a paracellular barrier in epithelial and endothelial cells protecting them from the external environment. Two different classes of integral membrane proteins constitute the tight junction strands in epithelial cells and endothelial cells, occludin and members of the claudin protein family. In addition, cytoplasmic scaffolding molecules associated with these junctions regulate diverse physiological processes like proliferation, cell polarity and regulated diffusion. In many diseases, disruption of this regulated barrier occurs. This review will briefly describe the molecular composition of the tight junctions and then present evidence of the link between tight junction dysfunction and disease.Keywords
This publication has 130 references indexed in Scilit:
- Organization of multiprotein complexes at cell–cell junctionsHistochemistry and Cell Biology, 2008
- Dopamine Receptor Modulation of Hypoxic—Ischemic Neuronal Injury in Striatum of Newborn PigletsJournal of Cerebral Blood Flow & Metabolism, 2007
- Dexamethasone induces the expression of metalloproteinase inhibitor TIMP‐1 in the murine cerebral vascular endothelial cell line cENDThe Journal of Physiology, 2007
- Inflammatory bowel disease: is it really just another break in the wall?Gut, 2007
- Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's diseaseGut, 2007
- Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular InvolvementAmerican Journal of Human Genetics, 2006
- Involvement of estrogen receptor β in terminal differentiation of mammary gland epitheliumProceedings of the National Academy of Sciences, 2002
- Alterations at the Intercalated Disk Associated with the Absence of Muscle Lim ProteinThe Journal of cell biology, 2001
- Mutations in the Gene Encoding Tight Junction Claudin-14 Cause Autosomal Recessive Deafness DFNB29Cell, 2001
- Morphological factors influencing transepithelial permeability: A model for the resistance of theZonula OccludensThe Journal of Membrane Biology, 1978