Recombinant Desmodus rotundus Salivary Plasminogen Activator Crosses the Blood–Brain Barrier Through a Low-Density Lipoprotein Receptor-Related Protein-Dependent Mechanism Without Exerting Neurotoxic Effects
- 1 March 2007
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 38 (3) , 1036-1043
- https://doi.org/10.1161/01.str.0000258100.04923.84
Abstract
Background and Purpose— Desmoteplase, a recombinant form of the plasminogen activator DSPAα1 from Desmodus rotundus, may offer improved clinical benefits for acute ischemic stroke treatment over th...Keywords
This publication has 27 references indexed in Scilit:
- Reduction of Tissue Plasminogen Activator-Induced Matrix Metalloproteinase-9 by Simvastatin in AstrocytesStroke, 2006
- Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS)Stroke, 2006
- Vampire Bat Salivary Plasminogen Activator (Desmoteplase) Inhibits Tissue-Type Plasminogen Activator-Induced Potentiation of Excitotoxic InjuryStroke, 2005
- Tissue-Type Plasminogen Activator Crosses the Intact Blood-Brain Barrier by Low-Density Lipoprotein Receptor–Related Protein-Mediated TranscytosisCirculation, 2005
- The Desmoteplase in Acute Ischemic Stroke Trial (DIAS)Stroke, 2005
- The Neurotoxicity of Tissue Plasminogen Activator?Journal of Cerebral Blood Flow & Metabolism, 2004
- Vampire Bat Salivary Plasminogen Activator (Desmoteplase)Stroke, 2003
- Intercommunications between brain capillary endothelial cells and glial cells increase the transcellular permeability of the blood–brain barrier during ischaemiaJournal of Neurochemistry, 2002
- Tissue Plasminogen Activator for Acute Ischemic StrokeNew England Journal of Medicine, 1995
- Structural Features Mediating Fibrin Selectivity of Vampire Bat Plasminogen ActivatorsPublished by Elsevier ,1995