Preliminary evidence for spectral opponency in the suppression of melatonin by light in humans
- 1 February 2004
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 15 (2) , 313-316
- https://doi.org/10.1097/00001756-200402090-00020
Abstract
Human adult males were exposed to light from blue light emitting diodes (18 lux; 29 μW/cm2) and from clear mercury vapor lamps (450 lux; 170 μW/cm2) during night-time experimental sessions. Both conditions suppressed nocturnal melatonin concentrations in blood plasma with the blue light more effective than mercury at melatonin suppression. No additive model incorporating opsin photopigments either alone or in combination could explain the results, but a model incorporating an opponent mechanism was consistent with the present data as well as data from previously published studies.Keywords
This publication has 19 references indexed in Scilit:
- Making (a) sense of non-visual ocular photoreceptionTrends in Neurosciences, 2003
- Melanopsin Is Required for Non-Image-Forming Photic Responses in Blind MiceScience, 2003
- Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in miceNature, 2003
- Melanopsin, Ganglion-Cell Photoreceptors, and Mammalian PhotoentrainmentJournal of Biological Rhythms, 2003
- Melanopsin ( Opn4 ) Requirement for Normal Light-Induced Circadian Phase ShiftingScience, 2002
- Phototransduction for human melatonin suppressionJournal of Pineal Research, 2002
- Phototransduction by Retinal Ganglion Cells That Set the Circadian ClockScience, 2002
- Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic PhotosensitivityScience, 2002
- Human melatonin suppression by light: a case for scotopic efficiencyNeuroscience Letters, 2001
- Absence of extraocular photoreception in diurnal and nocturnal rodents exposed to direct sunlightComparative Biochemistry and Physiology Part A: Physiology, 1981