Genes for members of the GATA‐binding protein family (GATA‐GT1 and GATA‐GT2) together with H+/K+‐ATPase are specifically transcribed in gastric parietal cells
- 28 February 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 340 (1-2) , 117-120
- https://doi.org/10.1016/0014-5793(94)80184-3
Abstract
MRNAs for novel DNA-binding proteins (GATA-GT1 and GATA-GT2) recognizing the (G/C)PuPu(G/C)NGAT(A/T)PuPy sequence and H+/K+-ATPase (proton pump) α subunit were detected in parietal cells of the rat gastric body mucosa by in situ hybridization. These results suggest that GATA-GT1 and GATA-GT2 together with H+K+-ATPase are transcribed specifically in gastric parietal cells and that the two DNA-binding proteins may have important roles in cell specific gene regulation. Furthermore, we could detect parietal cells in different states of gene expressionKeywords
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