Novobiocin Jaundice

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Abstract
THE clinical use of novobiocin is increasing because of its effectiveness in the treatment of staphylococcal infections. Toxic reactions1 , 2 include mild diarrhea (37 per cent), skin rashes (8.9 per cent), fever (2 per cent), eosinophilia (1.47 per cent), gastrointestinal irritation with nausea (1.3 per cent) and leukopenia (0.6 per cent).During novobiocin treatment yellowish discoloration of the skin and sclerae occasionally appears (0.6 per cent).2 The pigment is believed to be a degradation product of the drug and not related to hepatic dysfunction.1 2 3 However, chronic toxicity studies on dogs and rats demonstrated that hepatic degeneration may occur.4 The only clinical . . .