Tumor-induced osteomalacia. Evidence of a surgically correctable alteration in vitamin D metabolism
- 6 February 1981
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 245 (5) , 492-493
- https://doi.org/10.1001/jama.245.5.492
Abstract
A 15 yr old boy was treated for nonfamilial hypophosphatemic rickets. Treatment with ergocalciferol, 100,000 units/day, and phosphorus, 2-4 g/day, failed to alleviate the rickets. Levels of 1.alpha.,25-dihydroxyvitamin D were low while levels of 25-hydroxyvitamin D were elevated. After removal of a benign fibroma, the levels of 1.alpha.,25-dihydroxyvitamin D increased, the serum phosphorus level became normal and the osteomalacia was cured. The alteration of vitamin D metabolism and associated hypophosphatemia in oncogenic osteomalacia is a potentially reversible cause of bone disease mediated by the tumor.This publication has 5 references indexed in Scilit:
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- Radioligand receptor assay for 25-hydroxyvitamin D2/D3 and 1 alpha, 25-dihydroxyvitamin D2/D3.Journal of Clinical Investigation, 1976