HPLC DETERMINATION OF DAUNORUBICIN AND DAUNORUBICINOL IN HUMAN-PLASMA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 27  (3) , 102-104
Abstract
A high performance liquid chromatographic method for the quantitative simultaneous measurement of daunorubicin and its active metabolite, daunorubicinol, at low concentrations in human plasma was described. The advantages of this method were specificity, sensitivity, minimal preanalysis work-up and small sample size. The method was sensitive for plasma levels of daunorubicin and daunorubicinol as low as 10 ng/ml. Preliminary dosages in plasma from leukemic patients treated with a 4 h infusion of 75 mg/m2 daunorubicin as free drug or complexed with DNA were reported. The results suggested a slower disposition of the daunorubicin-DNA complex.

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