CENTRAL AND PERIPHERAL ACTION OF SUPPRESSOR CELLS IN CONTACT SENSITIVITY IN GUINEA-PIG
- 1 January 1976
- journal article
- research article
- Vol. 30 (4) , 593-597
Abstract
Suppressor cells were demonstrated in the spleen of guinea-pigs made specifically unresponsive to dinitrofluorobenzene (DNFB) with dinitrobenzene sulfonic acid (DNBSO3). Transfusion of these cells at the same time as sensitization with DNFB, produced a significant reduction in the immunoblasts proliferating in the draining lymph node 4 days later. Transfusion on the day of skin testing produced no greater suppression of skin reactivity than cells taken from animals made hyporeactive to DNFB by contact with dinitrothiocyanate benzene (DNTB). There are at least 2 sites at which suppressor cells can act. In the case of total unresponsiveness induced by DNBSO3, action is both central and peripheral. In the case of hyporeactivity induced by DNTB, in which there is no defect in proliferation of thymus-derived cells in response to antigen, the action of these cells is confined to the periphery. Results of spleen weight studies suggest that suppressor cells homing in the spleen respond by proliferation to epicutaneously applied DNFB.This publication has 4 references indexed in Scilit:
- Epicutaneous induction of hyporeactivity in contact sensitization. Demonstration of suppressor cells induced by contact with 2,4-dinitrothiocyanatebenzene.1975
- Reversal by cyclophosphamide of tolerance in contact sensitization. Tolerance induced by prior feeding with DNCB.1975
- Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activityNature, 1974
- Studies on the Ability of the Subcellular Fractions of Epidermis, Painted in vivo with DNFB, to Cause Contact Sensitization in the Guinea PigInternational Archives of Allergy and Immunology, 1970